NanoActive™ PhytoRetin DuoNano-Encapsulated Dual Botanical Retinoid
Dual-phase botanical smoothing × retinoid-like renewal
Smooth today. Renew tomorrow.
Made with PURISOME® FlexVes™ liposome technology
PuriPharm Co. Ltd. · Innovation for health & beauty · www.puriactives.com
THE ANTI-AGING CHALLENGE · 抗老挑战
Visible skin aging runs on two different clocks
Seconds → hoursThe apparent dimension of aging — seen and felt
· Facial-expression-related skin micro-relief
· Temporary appearance of expression lines
· Surface irregularity and roughness
· The wrinkles consumers notice first — and most want to improve quickly
Weeks → monthsThe structural, biological dimension of aging
· Progressive loss of collagen and extracellular matrix
· Photoaging and cumulative oxidative stress
· Uneven pigmentation, slowed epidermal turnover
· Gradual loss of firmness and smoothness
Effective anti-aging care must answer both clocks — immediately visible smoothing, and progressive biological renewal.
THE CONCEPT · 产品概念
Two botanical strategies, two timelines, one advanced delivery platform
Acmella oleracea extract
Fast-phase botanical smoothing, targeting the appearance of expression lines
Bakuchiol
Renewal phase — retinoid-like collagen and photoaging care
PURISOME®
Nano-liposome platform unifying protection, delivery, and release
PhytoRetin Duo is designed to combine the two strategies — complementary, not redundant.
PRODUCT AT A GLANCE · 产品概览
PhytoRetin Duo at a glance
| Item | Details |
|---|---|
| INCI names | ACMELLA OLERACEA EXTRACT / BAKUCHIOL |
| Positioning | Dual-phase botanical smoothing × retinoid-like renewal |
| Technology platform | PURISOME® FlexVes™ liposome technology — PuriPharm’s proprietary nano-liposome platform |
| Core benefits | Instantly visible smoothing · expression-line appearance care · collagen support · photoaging care · tone and texture improvement |
| Applications | Facial serums · eye care · night repair · sensitive-skin anti-aging · scalp essences |
A phospholipid bilayer vesicle encapsulating both botanical actives
Smooth today. Renew tomorrow.
EFFICACY ARCHITECTURE · 功效架构
Why dual-phase anti-aging?
Minutes → days
Instant — the apparent level
· Rapidly and visibly smooths skin micro-relief
· Expression-line appearance care
· Surface refinement consumers can perceive quickly
Driven by Acmella oleracea extract
Weeks → months
Renewal — progressive biological renewal
· Retinoid-like renewal and collagen support
· Extracellular matrix protection and photoaging care
· Gradual improvement in tone, texture, and firmness
Driven by bakuchiol
One ingredient answers today’s mirror; the other invests in tomorrow’s skin.
ACTIVE ONE · FAST PHASE · ACMELLA
Acmella oleracea — plant science and active chemistry
A precision botanical for expression-line appearance.Acmella oleracea (the “electric daisy”) is an Asteraceae plant whose aerial parts are rich in N-alkylamides — most notably spilanthol, which gives the extract its signature sensory and smoothing activity. In cosmetics, the extract is positioned for rapidly visible smoothing and refinement of skin micro-relief, especially in expression-active areas such as the eye contour.
Active chemistry
· Spilanthol (N-isobutyl-2E,6Z,8E-decatrienamide) — the principal alkylamide in the flower heads
· One of the bioactive N-isobutylamides isolated and identified from Spilanthes acmella (synonym of Acmella oleracea)
· Lipophilic character — ideally suited to encapsulation in phospholipid vesicles
Cosmetic positioning:rapidly visible smoothing · expression-line appearance care · refinement of skin micro-relief
Sources: Ramsewak RS, et al. Phytochemistry. 1999;51(6):729–732. · Savić SM, et al. Int J Cosmet Sci. 2025;47(2):362–382. doi:10.1111/ics.13034
ACTIVE ONE · MECHANISM · 机制
Rapid smoothing — the story of expression lines
The biology of expression lines
1 Repeated facial movements create temporary mechanical folds in the skin surface
2 The folds alter skin micro-relief — fine surface lines appear around the eyes and mouth
3 With age and slowing turnover, the temporary creases become increasingly persistent and visible
Ex vivo evidence
In an ex vivo nerve–muscle co-culture model, Acmella oleracea extract produced a rapid, dose-dependent, and fully reversible inhibition of muscle-fiber contraction frequency.
Contractile activity recovered within one hour of washout — supporting a gentle, non-destructive cosmetic mode of action.
This evidence supports cosmetic smoothing claims only — no pharmacological or neuromuscular claims are made.
Acmella extract delivers rapidly perceptible smoothing of expression-line appearance — the “fast” half of the dual-phase strategy.
Source: Demarne F, Passaro G. Use of an Acmella oleracea extract in an anti-wrinkle cosmetic composition. US Patent 7,531,193 B2. 2009.
ACTIVE ONE · CLINICAL EVIDENCE · 临床证据
Acmella — measurable smoothing on human skin
Study design
· Test system: human volunteers, eye-contour and perioral areas
· Design: randomized, split-face, controlled reference
· Test product: serum containing Acmella oleracea extract
· Duration: 2 weeks, twice daily
· Endpoints: hydration, smoothness, roughness, desquamation, wrinkle parameters
+10–40%Skin hydration (p < 0.05)
~+15%Skin smoothness (p < 0.05)
−20–30%Skin roughness (p < 0.05)
~−15%Wrinkle parameters (p < 0.05)
Tolerability:no eye-irritation potential (HET-CAM test), and spilanthol did not permeate porcine-ear skin — supporting a favorable topical safety profile.
Source: Savić SM, et al. Int J Cosmet Sci. 2025;47(2):362–382. doi:10.1111/ics.13034 · Ingredient-level evidence (Grade B) — not finished-product data on PhytoRetin Duo.
ACTIVE TWO · RENEWAL PHASE · BAKUCHIOL
Bakuchiol — the modern botanical retinol alternative
A phenolic monoterpene isolated from the seeds of Psoralea corylifolia. Structurally unrelated to retinoids, bakuchiol is a functional analog of retinol — acting on overlapping renewal pathways without retinol’s signature irritation.
· Retinoid-like gene-expression signature, with an entirely different molecular structure
· Photostable — suitable for morning and evening use
· Antioxidant activity supporting photoaging care
· Clinically demonstrated better tolerability than retinol
Molecular profile
Bakuchiol · phenolic monoterpene (meroterpene)
C₁₈H₂₄O · molecular weight 256.4
Lipophilic — ideally suited to lipid-bilayer encapsulation
“Retinoid-like” describes functional similarity — not retinoic-acid-receptor agonism.
Sources: Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221–230. · Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289–296.
ACTIVE TWO · MECHANISM · 机制
Bakuchiol — renewal across four dimensions
Collagen support — gene-expression studies show up-regulation of collagen types I and IV, and stimulation of type III collagen in mature fibroblasts.
Extracellular matrix protection — supports the dermal matrix environment that underlies firmness and visible wrinkle depth.
Antioxidant defense — proven antioxidant activity against oxidative stress, the central driver of photoaging.
Tone & pigmentation care — clinically observed improvement in the appearance of pigmentation, complementing the anti-wrinkle benefit.
A multi-pathway botanical acting on the structural timeline of skin aging — measured in weeks and months, not minutes.
Sources: Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221–230. · Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289–296.
ACTIVE TWO · MOLECULAR EVIDENCE · 分子证据
A retinoid-like molecular signature
Gene-expression profiling — CHAUDHURI & BOJANOWSKI (2014)
DNA microarray analysis on skin models showed a broad overall similarity between the gene-expression effects of bakuchiol and retinol — despite no structural resemblance between the two molecules. The similarity was confirmed gene by gene and validated at the protein level by ELISA and histochemistry. Key renewal markers — collagens I, III, IV and aquaporin 3 — were all modulated in a retinoid-like direction.
· Microarray — retinoid-like modulation of the skin gene-expression profile
· Protein level — collagen stimulation confirmed by ELISA and histochemistry
· Clinical case — twice-daily use for 12 weeks improved fine lines, wrinkles, pigmentation, elasticity, and firmness
Functional similarity — without retinol-associated adverse effects in this study.
Claim boundary: bakuchiol is described as retinoid-like / retinol-inspired — not as a retinoic-acid-receptor agonist.
Source: Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221–230. doi:10.1111/ics.12117
ACTIVE TWO · CLINICAL EVIDENCE · 临床证据
Head-to-head against retinol — Dhaliwal et al., 2019
Study design
· Design: prospective, randomized, double-blind
· Subjects: 44 (facial photoaging)
· Regimen: bakuchiol 0.5% cream twice daily vs retinol 0.5% cream once daily
· Duration: 12 weeks, assessed at weeks 0/4/8/12
· Endpoints: wrinkle surface area (image analysis), physician-graded pigmentation, tolerability
The two compounds showed no statistically significant difference on wrinkle and pigmentation endpoints. Photoaging improvement was comparable — while the bakuchiol group reported significantly less facial scaling and stinging.
Source: Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289–296. doi:10.1111/bjd.16918 · Ingredient-level evidence (Grade B).
THE DUO SYSTEM · 双活性体系
Two timelines, one active system
Fast phase · Acmella oleracea extract
Rapidly visible smoothing · expression-line appearance care · surface and micro-relief refinement
+
Renewal phase · Bakuchiol
Collagen support · extracellular matrix protection and photoaging care · tone and texture improvement
PhytoRetin Duo — instant + progressive beauty performance
A two-phase strategy built on complementary botanical mechanisms — ingredient-level evidence; no combination-synergy claim is made.
DELIVERY PLATFORM · 递送平台
PURISOME® FlexVes™ liposome technology
PURISOME® is PuriPharm’s proprietary advanced nano-liposome platform, built on more than a decade of nano-delivery R&D and industrialization experience. Both botanical actives are encapsulated within skin-affine phospholipid bilayer vesicles.
01 Encapsulation & protection — protects oxidation- and degradation-prone actives, extending shelf-life stability.
02 Enhanced penetration — promotes interaction with the stratum corneum, deposition, and bioavailability.
03 Sustained release — gradual, controlled release extends contact time with a gentler skin feel.
04 Formulation elegance — improves formulation compatibility and sensory performance.
Phospholipid bilayer vesicle — the PURISOME® carrier structure
PURISOME® SCIENCE · 科学
Why nano-scale lipid delivery?
Fluorescence skin cross-sections — the smaller the lipid vesicle, the deeper it reaches into the skin (particle size decreases a → c). Redrawn from Verma DD, et al. Int J Pharm. 2003;258:141–151.
Particle size determines deposition.Reducing vesicle size increases the total contact area with skin, supporting more efficient delivery into its superficial structures.
Nano-scale carriers distribute between superficial corneocytes and deposit in the skin’s shallow structures.
Large particles stay on the surface; nano-scale vesicles spread, conform, and deposit where they can make a difference.
PURISOME® engineers carriers to the nano scale — because particle size decides how far an active can go.
Source: Verma DD, Verma S, Blume G, Fahr A. Int J Pharm. 2003;258(1–2):141–151. · Delivery-platform literature (Grade C) — the scientific basis of the PURISOME® approach.
PURISOME® SCIENCE · 科学
Skin-affine phospholipid delivery
Barrier interaction — phospholipid vesicles are structurally compatible with the skin’s own lipid environment, adsorbing to and interacting with the stratum-corneum lipid matrix.
Sustained delivery — encapsulated actives release progressively at the skin surface and in shallow structures — extending contact time and smoothing transient concentration peaks.
Moisture-support film — a continuous nano-scale lipid film supports the barrier’s water-retention function.
The smaller the particles, the more continuous the surface film formed by lipid nanoparticles — effective surface coverage and contact increase accordingly.
A carrier built in the skin’s own chemical language — welcomed, not resisted.
Sources: Cevc G, Blume G. Biochim Biophys Acta. 1992;1104:226–232. · Honeywell-Nguyen PL, et al. Adv Drug Deliv Rev. 2004;56(5):603–631. · Delivery-platform literature (Grade C).
PURISOME® SCIENCE · 科学
The follicular reservoir and targeted delivery
Follicular deposition concept — surface (a), infundibulum (b), and deep-follicle (c) delivery zones. SC: stratum corneum · E: epidermis · D: dermis. Redrawn from Patzelt & Lademann.
The hair follicle as a reservoir and shunt pathway for lipid carriers of suitable particle size.
A size-selective pathway — nanoparticles can enter open hair follicles; in porcine-skin models, nm-scale particles reached the deepest follicular regions, driven by a “gear-pump” effect of hair movement.
A built-in reservoir — particles deposited in follicles can be stored for days, supporting prolonged local release of encapsulated actives.
Scalp relevance — high follicular density makes the scalp a natural target for follicular delivery — a technical rationale for premium scalp essences.
Sources: Patzelt A, et al. Eur J Pharm Biopharm. 2011;77(3):427–436. · Lademann J, et al. Skin Pharmacol Physiol. 2007;20(5):232–238. · Vogt A, et al. J Invest Dermatol. 2006;126(6):1316–1322. · Delivery-platform literature (Grade C).
COMMERCIAL OPPORTUNITY · SKINCARE APPLICATIONS
Skincare applications
· Anti-aging serums — the flagship format of the dual-phase positioning
· Eye care — crow’s-feet smoothing + progressive renewal
· Expression-line serums — precision care for high-movement areas
· Premium night serums — the overnight renewal narrative
· Retinol-alternative products — botanical renewal without retinol irritation
· Sensitive-skin anti-aging — a gentle renewal positioning
· Brightening + anti-aging — pigmentation care combined with anti-wrinkle care
· Neck & décolleté care — smoothing care for delicate expression zones
One active system — an entire premium anti-aging product line.
COMMERCIAL OPPORTUNITY · SCALP & HAIR
Scalp & hair care opportunities
Positioning within strict evidence boundaries
· Scalp renewal — bakuchiol’s retinoid-like renewal logic extends naturally to scalp skin
· Antioxidant scalp care — defending the follicular microenvironment against oxidative stress
· Healthy scalp environment — conditioning and barrier support
· Scalp anti-aging concept — the scalp ages like facial skin, yet rarely receives the same care
· Premium scalp-essence positioning — a differentiated, science-driven story
The PURISOME® scalp advantage
The scalp carries the highest density of terminal hair follicles in the human body.
PURISOME® nano-lipid carriers are sized within the range indicated by follicular-delivery literature, depositing in the follicular reservoir — enabling prolonged, localized release at the follicle.
Evidence discipline: the scalp positioning is built on ingredient-level skin evidence and delivery-platform rationale. No direct human hair-growth claim is made for either active.
Sources: Patzelt A, et al. Eur J Pharm Biopharm. 2011;77(3):427–436. · Lademann J, et al. Skin Pharmacol Physiol. 2007;20(5):232–238.
FOR FORMULATORS · 致配方师
Formulation opportunities
PURISOME® encapsulation is designed for formulation compatibility and sensory elegance, allowing PhytoRetin Duo to fit a broad range of leave-on formats.
| Serumslight daily care | Essenceslayered routines | Creamsrich barrier formats | Lotionsface & body |
| Eye productsexpression-zone care | Scalp essencesfollicle targeting | Leave-on scalp carereservoir release | Night repairrenewal ritual |
Recommended use level, pH range, process conditions, and full INCI composition: see PuriPharm TDS/PDS technical documentation (available on request).
BRAND LANGUAGE · CLAIM ARCHITECTURE
Claim architecture
Instant claim“Rapidly and visibly smooths the appearance of expression lines”
Progressive claim“Retinoid-like renewal — collagen support and photoaging care”
Technology claim“Advanced phospholipid delivery, sustained release”
Consumer language“Smooth today. Renew tomorrow.”
Every claim layer maps to a defined evidence grade — ingredient-level clinical data, platform literature, or mechanistic rationale — keeping marketing language permanently aligned with scientific support.
WHY PHYTORETIN DUO · 商业价值
Why choose PhytoRetin Duo?
01 A differentiated dual-phase story — instant smoothing and progressive renewal in one active, built on two complementary botanicals.
02 Clinical evidence support — bakuchiol’s 12-week randomized double-blind head-to-head against retinol; in-vivo human smoothing data for Acmella.
03 Proprietary delivery platform — PURISOME® FlexVes™ liposome technology for protection, penetration support, and sustained release.
04 Formulation versatility — one encapsulation system serving facial, eye, night-repair, and scalp-essence product lines.
05 A marketing-ready narrative — “Smooth today. Renew tomorrow.” translates complex science into a claim architecture consumers understand.
APPLICATION MATRIX · 创新平台
Application matrix — skin & scalp
| Category | Fast-phase role (Acmella) | Renewal-phase role (bakuchiol) | Platform role (PURISOME®) |
|---|---|---|---|
| Anti-aging serum | Rapid smoothing of micro-relief | Collagen support and photoaging care | Stability + sustained release |
| Eye care | Crow’s-feet appearance care | Firmness and texture improvement | Gentle delivery for delicate areas |
| Night repair | Overnight surface refinement | Progressive retinoid-like renewal | Extended contact, low-peak exposure |
| Scalp essence | Scalp surface conditioning | Scalp renewal and antioxidant care | Follicular-reservoir targeting |
All roles shown are evidence-based positionings — intended to combine synergistically within the same formulation system.
PURIPHARM CO. LTD. · 浦瑞生物医药
Botanical wisdom, advanced delivery, dual-phase renewal.
NanoActive™ PhytoRetin Duo — Smooth today. Renew tomorrow.
PuriPharm Co. Ltd.
Building 6, 1366 Hongfeng Road, Huzhou, Zhejiang, China · www.puriactives.com · +86 572-2745768
Key scientific literature
Dhaliwal S, et al. Br J Dermatol. 2019;180(2):289–296. · Chaudhuri RK, Bojanowski K. Int J Cosmet Sci. 2014;36(3):221–230. · Savić SM, et al. Int J Cosmet Sci. 2025;47(2):362–382. · Demarne F, Passaro G. US Patent 7,531,193 B2. 2009. · Ramsewak RS, et al. Phytochemistry. 1999;51(6):729–732. · Verma DD, et al. Int J Pharm. 2003;258:141–151. · Cevc G, Blume G. Biochim Biophys Acta. 1992;1104:226–232. · Patzelt A, et al. Eur J Pharm Biopharm. 2011;77(3):427–436. · Lademann J, et al. Skin Pharmacol Physiol. 2007;20(5):232–238. · Vogt A, et al. J Invest Dermatol. 2006;126(6):1316–1322.
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