P U R I P H A R M   C O . ,   L T D .

PURIACTIVES® · NANOACTIVE™ Nanoliposome Series

NanoActive™ GalaBiome™

Nanoliposomal Prebiotic Barrier Platform

Microbiome × Hydration × Barrier

PuriPharm Co. Ltd.

 

PARADIGM SHIFT

Moisturization Is More Than Adding Water

Skin hydration is an ecosystem function.

Traditional moisturization focuses on humectants, occlusives, and emollients. Modern skin science shows that skin hydration is an ecosystem function created by multiple interacting factors.

SIX KEY FACTORS

Lipid architecture; natural moisturizing factor (NMF); tight junctions; water transport; the acid mantle; and the skin microbiome.

A MUTUALLY SUPPORTIVE LOOP

Healthy microbiome ↕ healthy barrier ↕ healthy hydration

The three dimensions reinforce one another. An imbalance in any one dimension can propagate through the whole system—this is the scientific basis of “ecosystem hydration.”

Reference: Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

MICROBIOME × BARRIER

Microbiome & Barrier: A Bidirectional Symbiotic Defense Network

DEFENSE PATHWAY

Microbial barrier → acid mantle → metabolites/innate signals → keratinocyte differentiation → tight junctions → ceramide lipid barrier

TEWL ↓ · HYDRATION ↑

Lower transepidermal water loss and improved skin hydration

Healthy commensal microorganisms help build four layers of defense:

PHYSICAL

Commensals occupy ecological niches and reinforce the integrity of surface defenses.

CHEMICAL

Metabolism produces organic acids that help maintain the acid mantle.

MICROBIAL

Competition for nutrients and adhesion sites limits the dominance of opportunistic microbes.

IMMUNE

Contributes to homeostatic regulation of innate and adaptive immune signaling.

Healthy commensals do more than simply exist on the skin surface; they actively participate in the skin’s defense network.

Reference: Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

PRODUCT OVERVIEW

One Platform. Four Biological Dimensions.

SELECTIVE PREBIOTIC POLYOL

Lactitol: a lactose-derived disaccharide polyol that supports a healthy skin microbiome through selective prebiotic logic—selective nourishment rather than broad-spectrum feeding.

HYDRATION & BARRIER BIOLOGY

XAX ternary sugar-derivative system: Xylitylglucoside + Anhydroxylitol + Xylitol—multi-pathway hydration biology spanning water reserves, water circulation, and barrier lipids.

BIOMIMETIC LIPID INTERFACE

Phospholipids: amphiphilic structures analogous to biological membranes, creating a biomimetic lipid interface while supporting barrier lipids.

ADVANCED DELIVERY ARCHITECTURE

NanoActive™ nanoliposomes: nanoscale phospholipid vesicles encapsulate the aqueous phase of sugar-based actives for uniform distribution, local retention, and synergistic delivery.

Biome × hydration × barrier × delivery—one platform, four biological dimensions.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

LACTITOL

Lactitol | Selective Prebiotic Logic from Sugar Science

IDENTITY

Lactitol is a lactose-derived disaccharide polyol. Its value is not limited to humectancy; it lies in the prebiotic potential created by selective fermentation.

Feed the beneficial ecosystem, rather than simply feeding everything.

SCIENTIFIC EVIDENCE

Pure-culture screening compared how broadly different candidate prebiotic substrates were used by microorganisms:

• Lactitol was used with high specificity by Lactobacillus-related strains;
• Common substrates such as galacto-oligosaccharides and fructo-oligosaccharides were used by a broader range of microorganisms;
• The study reported that this degree of selectivity had not been observed among previously established prebiotics.

This selective utilization profile makes lactitol an ideal sugar-based nutritional substrate for targeted support of beneficial microbiota.

In-vitro pure-culture evidence for lactitol’s prebiotic mechanism supports its selective nourishment rationale.

Reference: Mäkeläinen H, Saarinen M, Stowell J, Rautonen N, Ouwehand AC. Beneficial Microbes. 2010;1(2):139-148. doi:10.3920/BM2009.0029.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

SELECTIVE ECOLOGY

Lactitol + Xylitol: Selective Skin Ecology

Selective polyol ecology—not “killing microbes,” but shaping ecological selection.

ECOLOGICAL SELECTION

The polyol combination provides selectively utilized nutritional substrates.

SUPPORT HEALTHY RESIDENT MICROBIOTA

Resident commensals gain a nutritional advantage.

LIMIT OPPORTUNISTIC DOMINANCE

Helps restore a more stable skin ecosystem.

In-vitro evidence

30–50%

In-vitro inhibition of growth for selected opportunistic microorganisms by the polyol system

≈100%

Increase in growth for selected healthy resident skin microorganisms

Suppress opportunistic advantage while supporting resident commensals—this is the essential difference between ecological selection and broad-spectrum antimicrobial strategies.

Reference: WO1995015149A1. Novel Cosmetic Compositions Containing Simple Polyols. 1995.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

ACID MANTLE

Supporting the Skin’s Acidic Ecosystem

The skin’s acidic environment is both a chemical barrier and a driver of microbial selection. A cleansing-induced rise in pH temporarily disrupts this balance; a polyol ecosystem-support system can help the skin return more quickly to its physiological acidic state.

Human study: 2% lactitol + 2% xylitol system

TIMELINE

Washing → pH rises and the acid mantle is temporarily disrupted → polyol ecosystem support → faster return to physiological acidic pH

4–6 h

Typical time required for the cleansing-induced pH rise to return to baseline

≈3 h

Recovery time after use of the polyol system (p < 0.05), with a more favorable microbial composition also observed

Reference: WO1995015149A1. Novel Cosmetic Compositions Containing Simple Polyols. 1995.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

XAX SYSTEM

XAX | From Humectancy to Hydration Biology

XAX = Xylitylglucoside + Anhydroxylitol + Xylitol. It is not an ordinary sugar-based humectant, but a hydration system acting simultaneously on three biological axes:

AXIS 01 · WATER RESERVOIR

Enhances water-reserve systems such as hyaluronic acid and chondroitin sulfate, building an internal skin “reservoir.”

AXIS 02 · BARRIER LIPIDS

Promotes ceramide-related synthesis and optimization of the lipid barrier, reducing water loss at its source.

AXIS 03 · WATER CIRCULATION

Modulates mechanisms related to tight junctions and epidermal water transport, enabling orderly movement of water through the skin.

Reservoir + lipids + circulation: from “holding water” to “managing water”—XAX forms the biological hydration backbone of GalaBiome™.

Reference: Garcia C, et al. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

CERAMIDE BIOLOGY

Reshaping the Lipid Logic of the Stratum Corneum

BRICK & MORTAR MODEL

Corneocytes are the “bricks,” while intercellular lipids such as ceramides form the “mortar.”

MECHANISM

XAX → de novo ceramide synthesis ↑ + cholesterol synthesis pathway (HMGCR-related) ↑ → more orderly intercellular lipid matrix → barrier strength ↑ → TEWL ↓

In-vitro evidence · De novo ceramide synthesis

Human skin explant model: 3% XAX versus untreated control (P < 0.05); differences for placebo and glycerol were not statistically significant (ns). Barrier improvement consistent with reduced TEWL was also observed.

Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

WATER RESERVOIR

Building an Internal Water Reservoir in the Skin

MECHANISM

XAX → acts on fibroblasts and keratinocytes → hyaluronic acid (HA) ↑ + chondroitin sulfate (CS) ↑ → extracellular-matrix water-binding capacity ↑ → expansion of the skin’s internal water reservoir

Hyaluronic acid and chondroitin sulfate are core glycosaminoglycans in dermal–epidermal water reserves and determine the skin’s water-storage capacity.

Cell model · Dose-dependent stimulation of chondroitin sulfate synthesis

In-vitro cultured human skin fibroblasts; mechanistic cell-model data. Differences in the two higher-concentration groups were statistically significant (P < 0.05). XAX also increased hyaluronic acid production in the cell model.

Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

WATER CIRCULATION

Hydration Is a Dynamic Flow

Hydration is not simply the static act of “holding water.”

HYDRATION FLOW

Reservoir → transport → retention → controlled loss

WATER FLOW PATHWAY

Dermis → epidermis · tight junctions → stratum corneum

XAX-REGULATED GENES

CGN (cingulin); CLDN-4/CLDN-5/CLDN-7 (claudins); and multiple genes related to epidermal differentiation, keratinization, and tight junctions.

Evidence derives from a gene-expression study in a 3D reconstructed epidermis model.

Water reservoir + water circulation + barrier retention—this is the scientific narrative that differentiates GalaBiome™ from a simple humectant.

Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

 

 

HUMAN EVIDENCE

Long-Lasting Hydration Beyond the Moment of Application

Human study: 25 female volunteers with dry skin used 3% XAX for 30 days. Benefits progressed over time, moving from immediate hydration toward structural improvement.

8 HOURS

Corneometry +6% and TEWL −8%—an immediately visible hydration response.

DAY 15

Hydration benefits remained stable while barrier indicators continued to improve.

DAY 30

Corneometry +11% and TEWL −15%—a transition from water replenishment to barrier-structure improvement.

Corneometry reflects stratum-corneum hydration, while TEWL was measured by evaporimetry. The same study also observed approximately 33% improvement in skin micro-roughness and approximately 25% improvement in desquamation.

Human research on XAX validates its multi-pathway hydration and barrier mechanisms—GalaBiome™ integrates them into a unified ecosystem platform.

Reference: Garcia C, Valin E, Hernandez E, Kern C, Roso A. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

RAMAN SCIENCE

Not All Water in the Stratum Corneum Is the Same

GLOBAL WATER

Overall hydration level of the stratum corneum.

PARTIALLY BOUND WATER

Water weakly associated with stratum-corneum structures.

UNBOUND WATER

Freely mobile water molecules.

KEY RAMAN FINDINGS — SUGAR-DERIVED COMPLEX

• All three water states improved: global, partially bound, and unbound water
• Water-retention capacity increased
• Lateral organization of stratum-corneum lipids became more orderly
• Keratin structural stability improved
• Effects were observed not only at the surface but also at a depth of 8 μm

CONFOCAL RAMAN DEPTH PROFILE

Surface: all three water states improved.

At 8 μm in the stratum corneum: improvement was also observed—benefits were not limited to the surface.

Reference: Fluhr JW, Tfayli A, Darlenski R, et al. J Biophotonics. 2023;16:e202200201. doi:10.1002/jbio.202200201.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

NANOLIPOSOME

From Prebiotic Molecules to a Biomimetic Delivery Interface

NANOLIPOSOME STRUCTURE

Aqueous core: an active aqueous pool of lactitol + XAX.

Phospholipid bilayer: surrounds the aqueous core.

External water phase: vesicles are dispersed in the continuous aqueous phase.

WHAT THE SYSTEM PROVIDES

• A reservoir for aqueous actives
• A phospholipid-bilayer interface
• More uniform distribution across the skin/scalp surface
• Synergy with a biomembrane-like lipid environment
• Improved delivery performance and user experience
• A dual microbiome + barrier platform

The phospholipid bilayer has an amphiphilic structure similar to biological membranes—this delivery architecture differentiates GalaBiome™ from an ordinary blended solution.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

DELIVERY DIRECTION

A Scientifically Established Delivery Direction

CARRIER DIRECTIONS ESTABLISHED IN PUBLIC PATENTS

Polyols such as lactitol and xylitol may be delivered in cosmetics as liposomes, micro/nanoparticles, or micro/nanocapsules.

MORE RECENT EXTENSIONS

Public patent research has also explored topical delivery of microbiome-related actives using phospholipid liposomes. Liposomes × microbiome care is a scientifically validated technical direction.

PATENT REFERENCES

WO1995015149A1 (1995) | Novel Cosmetic Compositions Containing Simple Polyols.

US20240216265A1 (2024) | Liposomal Vegan Probiotic Skin Treatment.

GalaBiome™’s polyol × liposome architecture is built on decades of publicly available scientific development.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

16 · INTEGRATED MECHANISM

The GalaBiome™ 4D Mechanism

NanoActive™ GalaBiome™

Balanced microbiome × optimized hydration × stronger barrier × improved skin & scalp comfort

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

POSITIVE FEEDBACK

Microbiome–Ceramide Crosstalk

FORWARD

Healthy microbiome → metabolic activity of commensals such as S. epidermidis → sphingomyelinase participates in host ceramide formation → ceramide homeostasis → barrier integrity + water retention ↑

REVERSE

A healthy, stable barrier with appropriate pH → dense lipid matrix and intact acid mantle → more secure commensal niches → a more stable microbiome

Positive Microbiome–Barrier Loop

Frontier science from skin-microbiome reviews indicates that healthy commensals participate in barrier-lipid homeostasis through metabolic activity. This is the theoretical foundation of GalaBiome™’s integrated microbiome × barrier design.

Reference: Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

18 · SCALP ECOSYSTEM

The Scalp Is Skin — With a Different Ecosystem

High sebum × abundant follicles: a distinctive microenvironment.

High microbial density: a more sensitive microbial balance.

Barrier readily affected by cleansing and the environment: more fragile water and lipid homeostasis.

Blow-drying/coloring/perming: thermal and chemical stress.

Environmental stress: dryness, pollution, and UV exposure.

Scalp care cannot focus only on dandruff removal or oil control; three dimensions must be managed together:

Scalp microbiome × scalp barrier × scalp hydration

GalaBiome™ = Scalp Ecosystem Conditioner

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

SCALP EVIDENCE

Scalp Hydration & Barrier Support

Human scalp study of a lactitol/xylitol system

28 volunteers (16 women + 12 men) · 10-day regimen · used in shampoo, conditioner, and leave-on scalp care.

+27%

Immediate moisturization: increase in scalp hydration immediately after application

+17%

Long-lasting moisturization: sustained scalp hydration

BARRIER & DESQUAMATION

TEWL results supported improved scalp-barrier integrity; videomicroscopy showed improvement in the appearance of scalp desquamation.

From hydration to barrier support, and from immediate to lasting benefits, the polyol ecosystem concept also applies to the scalp—providing human evidence for GalaBiome™ scalp applications.

Reference: Human scalp claim substantiation study, 28 volunteers, 10-day regimen, Dec. 2004. · WO2006061678A1. Cosmetic or Dermatological Compositions of Saccharose Substitutes.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

APPLICATIONS

One Biological Platform. Multiple Beauty Applications.

SKIN

• Barrier-repair serum
• Hydrating serum
• Cream for sensitive skin
• Microbiome-supporting moisturizing lotion
• Gel cream/sheet mask
• Gentle cleansing/post-cleansing care

SCALP & HAIR

• Scalp essence/scalp treatment
• Shampoo/conditioner
• Hair mask
• Leave-on scalp treatment
• Anti-dryness scalp care
• Sensitive-scalp care

Healthy scalp → a better environment for hair. Scalp hydration, comfort, and barrier support—combined with the emollient sensory profile and hair-care compatibility of phospholipids—make a healthy scalp the best environment for beautiful hair.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

FOR FORMULATORS

Designed for Modern Formulation Thinking

A single humectant mainly addresses immediate water attraction; a single prebiotic mainly supports a microbiome concept; traditional barrier lipids mainly provide lipid replenishment. GalaBiome™ integrates prebiotic support + hydration biology + barrier support + nanoliposomes into one platform.

Technical dimension	Humectant	Single prebiotic	GalaBiome™
Immediate hydration	✓	—	✓
Biological hydration	—	—	✓
Microbiome support	—	✓	✓
Barrier support	Limited	Indirect	✓
Nanoliposomal delivery	—	—	✓
Skin + scalp	Limited	Possible	✓

 

One addition covers four core dimensions of modern formulation.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

CLAIM ARCHITECTURE

Claim Architecture

MICROBIOME

• Supports skin ecosystem balance
• Helps maintain microbiome homeostasis
• Prebiotic skin and scalp care

HYDRATION

• Immediate and long-lasting moisturization
• Supports skin water reserves
• Optimizes water-retention capacity

BARRIER

• Helps strengthen the moisture barrier
• Supports ceramide and lipid homeostasis
• Helps reduce excessive water loss

SCALP

• Supports scalp hydration
• Improves scalp comfort
• Helps maintain scalp ecosystem balance
• Supports a healthy-looking scalp

TECHNOLOGY

• Nanoliposomal prebiotic platform
• Biomimetic phospholipid delivery
• Microbiome–barrier synergy

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

PRODUCT CONCEPTS

From Ingredient to Product Concepts

MICROBIOME BARRIER SERUM

Prebiotic ecosystem support; ceramide biology; long-lasting hydration.

SKIN ECOSYSTEM CREAM

Barrier strengthening; comfortable skin feel; suitable for dry and sensitive skin.

SCALP BIOME ESSENCE

Scalp hydration; improved appearance of flaking; scalp comfort.

HYDRATING BIOME SHAMPOO

Gentle cleansing; scalp-ecosystem friendly; post-wash comfort.

Four premium concept directions—from face to scalp, multiple expressions of the same platform.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

 

24 · SUMMARY

NanoActive™ GalaBiome™

Microbiome × Hydration × Barrier × Nanoliposome

A Smarter Ecosystem for Skin & Scalp.

PuriPharm Co. Ltd.

 

REFERENCES

Scientific References

JOURNALS

1. Lee HJ, Kim M. Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022;23:13071. doi:10.3390/ijms232113071.
2. Garcia C, Valin E, Hernandez E, Kern C, Roso A. Effect of a Simple Sugar-based Ingredient on Skin Moisturization: Biological Mode of Action and Clinical Effects. Asian J Beauty Cosmetol. 2023;21(1):13-27. doi:10.20402/ajbc.2022.0051.
3. Fluhr JW, Tfayli A, Darlenski R, et al. Glycerol and natural sugar-derived complex modulate differentially stratum corneum water-binding properties and structural parameters in an in vitro Raman-desorption model. J Biophotonics. 2023;16:e202200201. doi:10.1002/jbio.202200201.
4. Mäkeläinen H, Saarinen M, Stowell J, Rautonen N, Ouwehand AC. Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures. Beneficial Microbes. 2010;1(2):139-148. doi:10.3920/BM2009.0029.

PATENTS

1. WO1995015149A1 (1995) | Novel Cosmetic Compositions Containing Simple Polyols.
2. WO2006061678A1 (2006) | Cosmetic or Dermatological Compositions of Saccharose Substitutes.
3. US20240216265A1 (2024) | Liposomal Vegan Probiotic Skin Treatment.
4. WO2026167254A1 (2026) | Compositions Comprising Alditol and Alditol Derivatives for Supporting and Protecting the Skin.

NanoActive™ GalaBiome™ · PuriPharm Co. Ltd.

PuriActives® Ceramide E

The Advanced Pseudo-Ceramide Solution for Superior Skin Barrier Repair

PuriPharm Co. Ltd.

The Ceramide Challenge

Understanding the vital role of ceramides and the complex limitations of natural extraction in modern cosmetics.

The “Brick and Mortar” Model

The Epidermal Barrier
Ceramides account for over 50% of the stratum corneum lipids, acting as the essential ‘mortar’ holding the cellular ‘bricks’ together.

Moisture Retention
They uniquely form a structured lamellar network that powerfully binds water, actively preventing transepidermal water loss (TEWL).

Depletion Factors
Age, harsh chemicals, and environmental stressors rapidly deplete natural ceramides, inevitably leading to dryness, flaking, and irritation.

Natural Ceramide Limits

Natural ceramides are incredibly difficult and expensive to extract from plant or animal sources.

They exhibit notoriously poor solubility in both water and standard cosmetic oils.

Extremely high melting points (often over 90°C) make them challenging to formulate into stable emulsions.

Consequently, cosmetic formulators are often forced to use low, ineffective concentrations to prevent crystallization in the final product.

Introducing Ceramide E

A scientifically engineered, highly stable synthetic pseudo-ceramide developed by PuriPharm.

What is Ceramide E?

Scientific Profile
INCI: Cetyl-PG Hydroxyethyl Palmitamide.

It is a meticulously lab-created synthetic pseudo-ceramide designed to perfectly mimic the complex molecular structure and barrier function of natural epidermal sphingolipids.

The PuriActives® Advantage
It completely overcomes the formulation hurdles of natural ceramides. Ceramide E delivers identical barrier repair, profound hydration, and anti-inflammatory properties while remaining highly stable, safe, and cost-effective for modern skincare.

Replicating Nature

50% of Stratum Corneum Lipids

Biomimetic Structural Integrity

PuriActives® Ceramide E perfectly integrates into the skin’s natural lipid matrix. It acts as an identical substitute for the natural ceramides that naturally comprise half of your skin’s protective outer layer, ensuring long-lasting defense against environmental aggressors.

Mechanism of Action

Restoring the Lamellar Network

Ceramide E easily penetrates the upper layers of the epidermis, integrating directly into the compromised lipid matrix. It rapidly forms highly organized lamellar structures, effectively replacing lost intercellular “mortar”. This actively restores the structural integrity of the stratum corneum, locking in essential moisture while blocking external irritants.

Clinical Efficacies

Proven, measurable results in long-term skin hydration, structural protection, and barrier repair.

Core Skincare Benefits

Deep Hydration:
Massively enhances the skin’s capacity to retain moisture at a cellular level, dramatically improving overall elasticity, softness, and suppleness over continuous use.

Barrier Repair:
Actively replenishes the crucial lipid layer, effectively sealing microscopic epidermal cracks to stop transepidermal water loss (TEWL).

Soothing & Anti-Irritant:
Significantly reduces redness, flaking, and severe inflammation, making it highly recommended for sensitive, reactive, or eczema-prone skin types.

Anti-Aging Support:
Reinforces skin firmness and visibly minimizes the appearance of fine lines and wrinkles by maintaining optimal structural hydration and tissue resilience.

TEWL Reduction

Clinical applications demonstrate a dose-dependent, significant reduction in Transepidermal Water Loss (TEWL) compared to standard humectants, indicating a vastly fortified skin barrier.

24-Hour Hydration Trend

Unlike traditional humectants offering temporary relief, Ceramide E structurally locks in moisture, maintaining a significantly higher skin hydration index across a full 24-hour cycle.

Targeted Skin Conditions

Dry & Winter Skin
Eliminates flakiness and severe dryness by artificially rebuilding the compromised moisture barrier against harsh elements.

Sensitive & Atopic
Provides exceptional soothing relief for irritation, redness, and biologically compromised skin conditions like eczema.

Mature & Aging Skin
Combats the natural age-related decline of ceramide production, effectively restoring youthful firmness and tissue density.

Formulation Superiority

Formulators highly prefer PuriActives® Ceramide E as it completely bypasses the instability and crystallization risks of natural ceramides.

As a high-purity synthetic pseudo-ceramide, it offers exceptional batch consistency, prolonged shelf life, and effortless integration into complex cosmetic emulsions without degrading other actives.

Formulation & Applications

Technical guidelines and product versatility for cosmetic integration.

Versatile Applications

Facial Care
Essential for intensive barrier repair creams, high-end anti-aging serums, toners, and sensitive skin daily moisturizers.

Body Care
Highly effective in therapeutic body lotions, eczema-relief ointments, foot repair treatments, and winter care formulations.

Scalp & Hair
Excellent for anti-dandruff treatments, scalp soothing tonics, and deep conditioning hair masks to repair cuticle damage.

The Future of Barrier Care

“Synthetic pseudo-ceramides represent a critical breakthrough, delivering the profound barrier-repairing power of natural sphingolipids with unprecedented formulation stability.”

— Dermatological Research Perspectives

Formulation Process

1. Dispersion
Disperse the Ceramide E powder directly into the formulation’s designated oil phase.

2. Melting
Heat the entire oil phase to approximately 80°C to ensure complete dissolution.

3. Emulsion
Combine with the heated aqueous phase under high shear to form a stable emulsion.

4. Cooling
Cool the batch below 40°C before adding any heat-sensitive cosmetic actives.

Thank You

Discover the superior barrier repair of PuriActives® Ceramide E.

www.puriactives.com | sales@puripharm.com

UNLOCKING THE FULL POTENTIAL OF HEXYLRESORCINOL

HEXYLRESORCINOL: A MULTI-TARGET TONE-CORRECTION ACTIVE

POWERFUL BIOLOGY. DIFFICULT FORMULATION

WHY CONVENTIONAL HEXYLRESORCINOL CAN BE DIFFICULT TO USE

A DELIVERY-SYSTEM SOLUTION TO A MOLECULAR CHALLENGE

NANOACTIVE® HR: A FORMULATION-READY HEXYLRESORCINOL DELIVERY SYSTEM

BIOMIMETIC CARRIER. PROTECTED ACTIVE. OPTIMIZED INTERFACE

FROM FORMULATION LIABILITY TO DELIVERY ADVANTAGE

RECOMMENDED STABILITY VALIDATION PROGRAM

DESIGNED FOR MODERN SKINCARE FORMATS

HEXYLRESORCINOL ACTS BEYOND A SINGLE PIGMENTATION TARGET

PUBLISHED EVIDENCE SUPPORTS VISIBLE TONE IMPROVEMENT

STRONGER STRATEGIES THROUGH MULTI-PATHWAY DESIGN

A BROADER SKIN-QUALITY OPPORTUNITY

ONE ACTIVE. MULTIPLE PREMIUM PRODUCT STORIES

PROFESSIONAL INCORPORATION FOR CONSISTENT PERFORMANCE

DESIGNED FOR MULTI-PATHWAY FORMULATION STRATEGIES

NANOACTIVE® HR — TECHNICAL SPECIFICATIONS

FROM ACTIVE MOLECULE TO HIGH-PERFORMANCE DELIVERY SYSTEM

BRIGHTENING SCIENCE, DELIVERED MORE INTELLIGENTLY

SELECTED SCIENTIFIC AND TECHNICAL REFERENCES

Market Background

What Is Equol?

Why Equol for Skin Care?

Challenges of Conventional Equol

NanoActive® Delivery Platform

Product Concept

Core Benefits

Mechanism 1: Antioxidant Defense

Mechanism 2: ECM Support

Mechanism 3: Firmness & Elasticity

Mechanism 4: Photoaging Care

Mechanism 5: Soothing Care

Nano-Encapsulation Advantage

Formulation Applications

Formulation Guidelines

Claim Suggestions

Comparison with Other Anti-Aging Actives

Product Concept Formulas

PuriPharm Value Proposition

Safety & Regulatory Note

Scientific Background

References